IndraLab

Statements

UCHL1 activates TCF_LEF. 3 / 4
| 3
reach
"These observations imply that UCHL1 may contribute to CRC progression by activating the beta-catenin and TCF pathway through its deubi quitinating activity."
22641175
reach
"While UCH-L1 has been shown to inhibit alpha 2 -adrenergic receptor (AR) agonist mediated activation of ERK via a direct association with alpha 2A -AR receptor implicating a role of UCH-L1 in neuro-protection XREF_BIBR, it has also been documented that UCH-L1 up-regulates oncogenic beta-catenin and TCF and Akt signaling to induce tumor cell proliferation and migration contributing to tumor progression XREF_BIBR, XREF_BIBR."
24732420
reach
"In contrast, other studies have documented that UCH-L1 up-regulates beta-catenin and TCF via a positive feedback mechanism or exerts anti-apoptotic and growth stimulating effects, supporting an oncogenic potential of UCH-L1 [XREF_BIBR, XREF_BIBR]."
19945429