IndraLab

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Gastrodin increases the amount of USP4. 8 / 8
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"Furthermore, gastrodin significantly upregulated the expression of USP4 and increased the binding of USP4 to the insulin receptor.Considering the importance of the PI3K-Akt pathway in the pathogenesis of T2DM, we detected the effects of gastrodin on the PI3K-Akt pathway to further explore the underlying mechanism of gastrodin in ameliorating insulin resistance."
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"Thus, these results indicate that gastrodin promotes the phosphorylation of GATA1 and upregulate its transcriptional activity via the PI3K-Akt pathway, promotes USP4 gene transcription, and upregulates USP4 expression."
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"Furthermore, Gastrodin has been shown to upregulate the expression of USP4 and enhance the interaction between USP4 and insulin receptors to treat diabetes (118)."
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"Gastrodin, a compound derived from Gastrodia elata, has been reported to enhance the expression of USP4 and may represent a novel targeted treatment for T2D (118)."
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"Our results indicate that gastrodin promotes the phosphorylation of GATA1 via the PI3K/AKT pathway, enhances the transcriptional activity of GATA1, and then increases the expression level of USP4, thereby reducing the ubiquitination and degradation of insulin receptors and ultimately improving insulin resistance."
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"Bai et al. [1] indicated that gastrodin promotes the phosphorylation of GATA1, upregulates its transcriptional activity via the PI3K/AKT pathway, and promotes USP4 expression."
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"The results of the study showed that gastrodin promotes the phosphorylation of GATA1 via the PI3K/AKT pathway, increases the transcriptional activity of GATA1, and subsequently increases the expression level of USP4, thereby reducing the ubiquitination and degradation of insulin receptors, and ultimately improving insulin resistance."
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"Compared to the IR group, gastrodin upregulated the ratio of p-Akt/total Akt by 50.09, 153.81, and 155.27% and upregulated USP4 expression by 15.66, 84.50, and 143.24% at 10, 30, and 100 μg/ml, respectively."
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