IndraLab

Statements

Ubiquitin binds CYLD. 8 / 11
| 8
sparser
"CYLD binds linear ubiquitin."
35587511
sparser
"Since the N terminus and Lys63 side chain of ubiquitin are in close proximity, the most distal ubiquitin moiety, attached to the N terminus of the adjacent ubiquitin moiety bound to the distal ubiquit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18313383
sparser
"In both catalytic states, the distal Ub is bound to CYLD in a similar manner, and the scissile bond is located close to the catalytic residue, whereas the proximal Ub is bound in a manner specific to Met1- or Lys63-linked chains."
25686088
sparser
"However, modeling indicates that, similar to HAUSP and USP14, the Lys48 side chain of the distal ubiquitin would be occluded and that a Lys48-linked chain could not be extended from a ubiquitin molecu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
18313383
sparser
"The detection of CYLD bound to M1-Ub reveals another, LUBAC-independent, layer of crosstalk between the two deubiquitinases."
35587511
sparser
"These data reveal a direct, LUBAC-independent but OTULIN-dependent binding of M1-Ub to CYLD."
35587511
sparser
"We identified no Gly-Gly ubiquitination signature sites on CYLD by proteomic approaches, suggesting that the posttranslational modification is not ubiquitination itself and that the binding of CYLD to M1-Ub is non-covalent."
35587511
sparser
"We confirmed the specific binding of CYLD to M1-Ub in an OTULIN gene-dosage dependent manner ( xref , xref )."
35587511