IndraLab

Statements

GSK3 phosphorylates NPM1. 2 / 2
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"Although in vitro phosphorylation experiments ( xref ; xref ) show that GSK-3 can directly phosphorylate SRSF2, SRSF9, NPM1, PHF6, RBM8A, and PSF, this supports but does not prove that the phosphorylation occurs directly in vivo."
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sparser
"Gsk3 DKO reduced phosphorylation of the splicing factors RBM8A, SRSF9, and PSF as well as the nucleolar proteins NPM1 and PHF6, and recombinant GSK-3β phosphorylated these proteins in vitro RNA-Seq of WT and Gsk3 DKO ESCs identified ∼190 genes that are alternatively spliced in a GSK-3-dependent manner, supporting a broad role for GSK-3 in regulating alternative splicing."
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