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BAP1 deubiquitinates BRCA1. 3 / 3
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"As a possible mechanism of BRCA1 stabilization by BAP1 transduction in this study, we speculated that the ubiquitination of BRCA1 protein might be directly deubiquitinated by BAP1."
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"We hypothesized that BAP1 might deubiquitinate BRCA1 and protect it from proteasome mediated degradation; this might explain the BRCA1 stabilization by the mutant BAP1 forms that retained the DUB activity."
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"BAP1 also controls G1/S cell cycle progression by regulating BRCA-1 [111], Ying Yang 1 (YY-1), and host cell factor 1 (HCF-1)"
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