IndraLab

Statements

COPS5 inhibits Ubiquitin. 3 / 4
| 1 2
reach
"Mechanistic studies showed that Jab1 induced ubiquitin independent proteasomal p14ARF degradation in gastric cancer cells."
32458234
reach
"While Csn5 is thought to impede the action of ubiquitin ligases through shaving cullins from their Rub1 and Nedd8 modification (and possibly also by deubiquitinating substrates bound to the cullins), the outcome of Rpn11 inhibition will depend largely on whether Rpn11 participates primarily in shaving substrates from their chains, promoting release and rescue, or in trimming the polyubiquitin tag, allowing for proteolysis quality control (XREF_FIG)."
14737189
eidos
"Indeed , ectopic expression of IFIT3 in U937 human myeloid cells resulted in the sequestration of JUN activation domain-binding protein 1 ( JAB1 ; also known as COPS5 ) , which limited ubiquitin - and proteasome-dependent degradation of cyclin-dependent kinase inhibitor 1B ( also known as p27 and KIP1 ) ."
23237964