IndraLab

Statements

COPS5 inhibits Ubiquitin. 6 / 7
| 1 5
reach
"Mechanistic studies showed that Jab1 induced ubiquitin independent proteasomal p14ARF degradation in gastric cancer cells."
32458234
reach
"Additionally, CSN5 induces non-ubiquitin proteasomal degradation of the tumor suppressor p14ARF [103]."
36497313
eidos
"Indeed , ectopic expression of IFIT3 in U937 human myeloid cells resulted in the sequestration of JUN activation domain-binding protein 1 ( JAB1 ; also known as COPS5 ) , which limited ubiquitin - and proteasome-dependent degradation of cyclin-dependent kinase inhibitor 1B ( also known as p27 and KIP1 ) ."
23237964
reach
"Moreover, JAB1 directly interacted with angiopoietin-like protein 2 (ANGPTL2) and attenuated its ubiquitin-mediated degradation through de-ubiquitylation (Xie et al. 2021)."
37365502
reach
"In this study, we demonstrated that Csn5 inhibits autophagy in M. oryzae by promoting ubiquitin-dependent Atg6 protein degradation and stabilizing the TOR pathway in autophagosome formation."
38594767
reach
"While Csn5 is thought to impede the action of ubiquitin ligases through shaving cullins from their Rub1 and Nedd8 modification (and possibly also by deubiquitinating substrates bound to the cullins), the outcome of Rpn11 inhibition will depend largely on whether Rpn11 participates primarily in shaving substrates from their chains, promoting release and rescue, or in trimming the polyubiquitin tag, allowing for proteolysis quality control (XREF_FIG)."
14737189