IndraLab

Statements

Kinase-active AKT1 activates MTOR. 7 / 7
4 3 |
bel
"Akt suppresses TSC1/2, leading to the activation of mTOR."
17210675
bel
"once Akt1 is activated, it initiates a cascade of phosphorylation events targeting mammalian target of rapamycin, mTOR, which in turn phosphorylates the p70S6 kinase and GSK3B"
15292521
bel
"The pathway consisting of PI3K, Akt, and mammalian target of rapamycin (mTOR), which is downstream of EGFR, is activated early in lung carcinogenesis.83 (-- indicated as early event by authors)"
18815398
bel
"Reduced Akt phosphorylation/activation may be responsible for the decreased mTOR signaling, as indicated by down-regulation of the phosphorylation of mTOR downstream target proteins, including 4EBP1 (Thr37/46), S6K1 (Thr389), and S6 (Ser235/236)."
20638473
bel
"once Akt1 is activated, it initiates a cascade of phosphorylation events targeting mammalian target of rapamycin, mTOR, which in turn phosphorylates the p70S6 kinase and GSK3B"
15292521
bel
"Akt suppresses TSC1/2, leading to the activation of mTOR."
17210675
bel
"The pathway consisting of PI3K, Akt, and mammalian target of rapamycin (mTOR), which is downstream of EGFR, is activated early in lung carcinogenesis.83 (-- indicated as early event by authors)"
18815398