A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

IndraLab

Statements

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reading

Kinase-active AKT1 activates MTOR. 7 / 7
4 3 |
bel
"Akt suppresses TSC1/2, leading to the activation of mTOR."
bel
"The pathway consisting of PI3K, Akt, and mammalian target of rapamycin (mTOR), which is downstream of EGFR, is activated early in lung carcinogenesis.83 (-- indicated as early event by authors)"
bel
"Reduced Akt phosphorylation/activation may be responsible for the decreased mTOR signaling, as indicated by down-regulation of the phosphorylation of mTOR downstream target proteins, including 4EBP1 (Thr37/46), S6K1 (Thr389), and S6 (Ser235/236)."
bel
"once Akt1 is activated, it initiates a cascade of phosphorylation events targeting mammalian target of rapamycin, mTOR, which in turn phosphorylates the p70S6 kinase and GSK3B"
bel
"The pathway consisting of PI3K, Akt, and mammalian target of rapamycin (mTOR), which is downstream of EGFR, is activated early in lung carcinogenesis.83 (-- indicated as early event by authors)"
bel
"Akt suppresses TSC1/2, leading to the activation of mTOR."
bel
"once Akt1 is activated, it initiates a cascade of phosphorylation events targeting mammalian target of rapamycin, mTOR, which in turn phosphorylates the p70S6 kinase and GSK3B"