IndraLab

Statements

USP22 increases the amount of FOXM1. 8 / 9
| 8
reach
"USP22 promotes the G1/S phase transition by upregulating FoxM1 expression via beta-catenin nuclear localization and is associated with poor prognosis in stage II pancreatic ductal adenocarcinoma."
24993031
reach
"USP22 promotes the G1/S phase transition by upregulating FoxM1 expression via promoting beta-catenin nuclear localization."
24993031
reach
"Similarly, in pancreatic ductal adenocarcinoma cells, USP22 promotes the G1/S transition and proliferation by upregulating the expression of FoxM1 [8], a key regulator of the G1/S and G2/M cell cycle transitions [32]."
32063746
reach
"USP22 promotes the G1/S phase transition by upregulating FoxM1 expression via beta-catenin nuclear localization and is associated with poor prognosis in stage II pancreatic ductal adenocarcinoma."
31485660
reach
"By contrast, treatment with NH Cl, an inhibitor of endosome-lysosome degradation pathway, fails to protect FoxM1 from degradation (Figure s3A), suggesting that USP22 promotes FoxM1 level through inhibiting its proteasomal degradation.As a deubiquitinase, USP22 exerts its biological function largely through protecting its downstream substrates from ubiquitination-mediated degradation ."
37398311
reach
"By contrast, treatment with NH Cl, an inhibitor of endosome-lysosome degradation pathway, fails to protect FoxM1 from degradation (Figure S3A), suggesting that USP22 promotes FoxM1 expression by inhibiting its proteasomal degradation.As a deubiquitinase, USP22 exerts its biological function largely through protecting its downstream substrates from ubiquitination-mediated degradation.27 Accordingly, we speculated that USP22 could be a deubiquitinase of FoxM1."
39246448
reach
"USP22 can increase the expression of foxhead box M1(FoxM1) by inducing β-catenin nuclear location which promotes the expression of FoxM1.Besides, in a study about USP5 in PC, it promoted tumorigenesis[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33038351
reach
"Mechanistically, it has been reported that USP22 induces β-catenin nuclear localisation and upregulates FoxM1 expression to promote G1/S cell cycle transition and cell proliferation (Ning et al., 2014)."
34733591