IndraLab

Statements

CDKN2C binds CYLD. 17 / 17
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"To investigate the effect of the CYLD-p18 axis in EBV lytic replication, CYLD was transfected into HK1-EBV and HONE1-EBV cells."
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"We also found that EBV deregulates the CYLD-p18 axis, which contributes to viral DNA replication and tumor growth."
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"In this paper, we identified CYLD as a deubiquitinase of CKI p18, offering mechanistic insights into the contribution of CYLD-p18 axis to the cell cycle progression."
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"Positive fluorescent signals were observed, which indicates CYLD interacts directly with p18."
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"CYLD interacts with p18."
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"CYLD interacts with p18."
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"Here we found that EBV drives a replication passive environment by deregulating the CYLD-p18 axis."
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"To better understand how CYLD regulates p18, we examined whether CYLD interacts with p18."
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"Therefore, we concluded that EBV deregulates the host CYLD-p18 axis to push host cells to provide suitable replication-passive cellular environments for EBV DNA replication."
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"The co-IP analysis revealed that the N-terminal region, especially amino acids 1-304 of CYLD, was critical for the interaction between CYLD and p18."
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"Further, PLA assay results showed the interaction between CYLD and p18 is by direct binding."
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"The co-IP analysis revealed that the N-terminal region, especially amino acids 1–304 of CYLD, was critical for the interaction between CYLD and p18 (Fig. xref )."
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"Further, PLA assay results showed the interaction between CYLD and p18 is by direct binding."
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"EBV altered the growth properties of infected cells by breaching the CYLD-p18 axis providing insights into the role of EBV in the pathogenesis of human epithelial cancers."
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"To better understand how CYLD regulates p18, we examined whether CYLD interacts with p18."
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"The reconstitution of CYLD-p18 axis could be a promising approach for EBV-positive cancer therapy."
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"As we found that CYLD is a deubiquitinase of p18 in regulating G1/S transition, which means that the CYLD-p18 axis may prevent EBV lytic replication by regulating cell cycle procession."
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