IndraLab

Statements

MTOR phosphorylates IRS1 on S312. 4 / 4
1 | 2 1
reach
"Phosphorylation of IRS-1 (Ser312) by P-mTOR promotes conformational changes and subsequent detachment from the receptor and degradation [XREF_BIBR], and inhibits potentiation of Akt by IGF-1R and IRS-1 signaling [XREF_BIBR]."
20863384
sparser
"The latter mechanism is responsible for the described feedback loop inhibition of Akt phosphorylation mediated by mTOR-dependent phosphorylation of IRS-1 at Ser312, the immediate downstream effector protein of the insulin-like growth factor-1 receptor (IGF-1R) [ xref , xref ]."
20863384
signor
"Mtor induced the serine phosphorylation of irs-1 (ser-636/639), and such phosphorylation was inhibited by rapamycin. These results suggest that tnf impairs insulin signaling through irs-1 by activation of a pi 3-kinase/akt/mtor pathway, which is antagonized by pten"
11287630
reach
"The latter mechanism is responsible for the described feedback loop inhibition of Akt phosphorylation mediated by mTOR dependent phosphorylation of IRS-1 at Ser312, the immediate downstream effector protein of the insulin like growth factor-1 receptor (IGF-1R) [XREF_BIBR, XREF_BIBR]."
20863384