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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

RPS6KB1 phosphorylated on T252 is kinase-active. 2 / 2

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bel

"A critical step in S6 kinase 1 (S6K1) activation is Thr(229) phosphorylation in the activation loop by the phosphoinositide-dependent protein kinase (PDK1)."

11914378

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bel

"from full text - T229 is situated in the catalytic domain of p70S6K, and in addition to T389, its phosphorylation is necessary for full activation of the protein. Residues T421 and S424 are situated in the autoinhibitory/pseudosubstrate domain of the C-terminus, and phosphorylation of these residues is proposed to be one of the early steps of p70S6K activation (2)."

16262259

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...