IndraLab

Statements

Modified MDM2 increases the amount of TP53. 12 / 12
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"Other target substrates of akt include the transcription factors FKHR and FoxO [XREF_BIBR], which when phosphorylated are inhibited, mdm2, which following phosphorylation translocates to the nucleus and inhibits transcription of p53 target genes and mTOR (mammalian target of rapamycin)."
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"In MDA-MB-435 and C4-2B cancer cells, 12-Chloracetyl-PPD induced G2/M cell cycle arrest, down-regulated mouse double minute 2 (MDM2) expression, up-regulated p53 expression, triggered apoptosis, and stimulated reactive oxygen species production."
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"In this study, we reported that ST induced the inhibition of E6 and E7 viral oncogene and MDM2 expression, while it led to increased levels of p53, which was transiently located to mitochondria."
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"Furthermore, cell survival was restored by expression of Mdm2 in Elavl1-/- cells, suggesting that HuR keeps p53 levels in check in progenitor cells and thereby promotes cell survival."
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"miR-122 by modulating cyclin G 1 / PP2A and MDM2 expression activates and stabilizes p53 protein expression in hepatocellular carcinoma cells [XREF_BIBR] but it is significantly down regulated in PC [XREF_BIBR]."
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"We hypothesized that MDM2 cerebral expression does not increase in response to increased p53 expression or increased levels of phospho-p53 (Ser15), an activated form of p53."
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"Our findings indicate a mechanism in which mitogens present in injury sites activate myocardial expression of the negative Tp53 regulator Mdm2, which transiently reduces Tp53 levels and facilitates cell cycle entry (XREF_FIG)."
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"38 HAUSP mediated deubiquitination can result in both the increase in Mdm2 levels promoting p53 degradation and the increase in p53 levels directly."
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"It has also been demonstrated that ARF can significantly activate p53 through sequestering the transcription of MDM2, which then increases the expression of the p53 target gene p21 [XREF_BIBR]."
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"After the addition of LPS, however, MDM2 expression was up-regulated, resulting in the down-regulation of p53 expression."
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"This degradation results in increased MDM2 levels that subsequently reduced p53 levels."
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"Some of these miRNAs are regulated by p53, and their modulation of MDM2 levels upregulates p53 levels and activity, effectively making this part of the negative-feedback loop."
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