IndraLab

Statements

Modified MDM2 increases the amount of TP53. 10 / 10
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"Some of these miRNAs are regulated by p53, and their modulation of MDM2 levels upregulates p53 levels and activity, effectively making this part of the negative-feedback loop."
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"After the addition of LPS, however, MDM2 expression was up-regulated, resulting in the down-regulation of p53 expression."
33456361
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"38 HAUSP mediated deubiquitination can result in both the increase in Mdm2 levels promoting p53 degradation and the increase in p53 levels directly."
19543236
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"Our findings indicate a mechanism in which mitogens present in injury sites activate myocardial expression of the negative Tp53 regulator Mdm2, which transiently reduces Tp53 levels and facilitates cell cycle entry (XREF_FIG)."
32877671
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"Furthermore, cell survival was restored by expression of Mdm2 in Elavl1-/- cells, suggesting that HuR keeps p53 levels in check in progenitor cells and thereby promotes cell survival."
19884656
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"This degradation results in increased MDM2 levels that subsequently reduced p53 levels."
25600590
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"We hypothesized that MDM2 cerebral expression does not increase in response to increased p53 expression or increased levels of phospho-p53 (Ser15), an activated form of p53."
15563574
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"It has also been demonstrated that ARF can significantly activate p53 through sequestering the transcription of MDM2, which then increases the expression of the p53 target gene p21 [XREF_BIBR]."
30845965
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"miR-122 by modulating cyclin G 1 / PP2A and MDM2 expression activates and stabilizes p53 protein expression in hepatocellular carcinoma cells [XREF_BIBR] but it is significantly down regulated in PC [XREF_BIBR]."
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"Other target substrates of akt include the transcription factors FKHR and FoxO [XREF_BIBR], which when phosphorylated are inhibited, mdm2, which following phosphorylation translocates to the nucleus and inhibits transcription of p53 target genes and mTOR (mammalian target of rapamycin)."
17488476