IndraLab

Statements

USP14 binds ERN1. 25 / 25
3 | 1 7 14
sparser
"A recent study demonstrated that USP14 interacts with the cytoplasmic region of IRE1 to inhibit ERAD under non-stress conditions xref ."
22792064
sparser
"USP14 interacted with the cytoplasmic region of IRE1alpha, and the endogenous interaction between USP14 and IRE1alpha was inhibited by ER stress."
19135427
reach
"IRE1alpha associated with USP14 under the non stressed condition."
19135427
sparser
"These results suggested that USP14 interacts with the C-terminal cytoplasmic region of inactive form of IRE1α."
19135427
sparser
"USP14 binding to the IRE1 protein for ER stress regulation indicates an important role in mutant Huntingtin-induced cell toxicity and the murine norovirus-caused infections [ xref , xref ]."
26097878
trips
"Usp14 interacted with IRE1 in control cells but less in mutant Htt-expressing cells."
24951540
sparser
"To evaluate the IRE1α–USP14 interaction under physiological conditions in mammalian cells, we examined the association of endogenous IRE1α and USP14 in MEF."
19135427
reach
"Previous studies have identified that USP14 can directly bind to IRE1alpha, and the endogenous interaction between USP14 and IRE1alpha is inhibited by ER stress [XREF_BIBR]."
33546413
sparser
"These results suggested that USP14 physiologically interacts with the inactive form of IRE1α under the non-stressed condition and dissociates from the activated form of IRE1α by ER stress."
19135427
reach
"Usp14 interacted with IRE1 in control cells but less in mutant Htt expressing cells."
24951540
biogrid
No evidence text available
24951540
sparser
"Although wild-type IRE1α, which was autophosphorylated by its overexpression, did not interact with USP14 ( Fig. 1 C, lane 2), IRE1α KN clearly interacted with USP14 ( Fig. 1 C, top panel, lane 3)."
19135427
reach
"USP14 interacted with the cytoplasmic region of IRE1alpha, and the endogenous interaction between USP14 and IRE1alpha was inhibited by ER stress."
19135427
sparser
"USP14 interacted with the cytoplasmic region of inactive IRE1α, and their association was inhibited by ER stress and IRE1α activation."
19748352
biogrid
No evidence text available
19135427
reach
"We determined whether IRE1alpha interacts with USP14 following the treatment with or without thapsigargin, which triggers ER stress by depletion of ER luminal calcium stores."
19135427
sparser
"Tunicamycin, which is an inhibitor of N-glycosylation in the ER, also inhibited the interaction of USP14 with IRE1α (data not shown)."
19135427
sparser
"We determined whether IRE1α interacts with USP14 following the treatment with or without thapsigargin, which triggers ER stress by depletion of ER luminal calcium stores."
19135427
sparser
"IRE1α associated with USP14 under the non-stressed condition ( Fig. 1 A, lane 2)."
19135427
reach
"USP14 interacts with IRE1alpha in control cells, but there is less interaction in mutant Htt cells."
33546413
sparser
"Similar to USP14, a mutant USP14 lacking the UBL domain [USP14(CT); Fig. 1 B], but not a mutant USP14 lacking the USP domain [USP14(NT); Fig. 1 B], was coimmunoprecipitated with IRE1α KN and IRE1α [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19135427
biogrid
No evidence text available
19135427
sparser
"Since activation status of IRE1α appeared to correlate with the dissociation of USP14 from IRE1α, we examined whether the interaction between USP14 and IRE1α is dependent on the kinase activity of IRE[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19135427
reach
"These results suggested that USP14 physiologically interacts with the inactive form of IRE1alpha under the non stressed condition and dissociates from the activated form of IRE1alpha by ER stress.Sinc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
19135427
sparser
"Usp14 interacted with IRE1 in control cells but less in mutant Htt-expressing cells."
24951540