IndraLab

Statements

USP47 activates apoptotic process. 6 / 6
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"USP47 induced apoptosis was potently counteracted by the NF-kappaB inhibitor, and cytoplasmic NF-kappaB was increased and nuclear NF-kappaB was decreased."
32761659
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"However, USP47 deficiency inhibits SCF (β‐TrCP) degradation of Cdc25A, promotes apoptosis, and enhances the cytotoxicity of anticancer drugs.F‐box dysfunction will affect the survival of tumor cells."
39812503
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"USP47-deficient MEF cells isolated from a USP47 knockout mouse model revealed that USP47 knockout significantly increased the levels of ultraviolet-induced apoptosis (Peschiaroli et al., 2010)."
34604226
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"For instance, USP47 has been shown to promote apoptosis in rat cardiomyocytes following I/R injury by activating NF‐κB. 7 Additionally, USP7 enhances ferroptosis by activating the p53/TfR1 pathway after I/R in the rat heart."
39985261
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"Downregulation of USP47 decreased apoptosis induced by ischemia/reperfusion injury, increased survivin and cytoplasmic NF-κB, and decreased cleaved caspase-3 and nuclear NF-κB. NF-κB inhibitors could effectively inhibit USP47-induced apoptosis, increase cytoplasmic NF-κB, and decrease nuclear NF-κB. Luciferase reporter genes showed that USP47 promoted NF-κB promoter activity."
34604226
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"USP47 promotes apoptosis in rat myocardial cells after ischemia and reperfusion injury via NF-kappaB activation."
32761659