IndraLab

Statements

NSFL1C binds VCPIP1. 12 / 12
4 | 4 4
sparser
"The inhibition of p97 ATPase activity can be reduced if both p47-binding sites are not occupied, and the metastable complex of VCIP135/p97/p47 would represent such a case: VCIP135 interacts with the p97/p47 complex that uses only one p47-binding site."
12473691
sparser
"Several lines of recent evidence suggest that ubiquitination may be implicated in the p97/p47 pathway; p47 binds to monoubiquitinated proteins and VCIP135 shows a deubiquitinating activity in vitro."
15749824
sparser
"VCIP135 cannot interact with p47 directly ( xref A)."
12473691
reach
"The p97 and p47 binding protein VCIP135 (VCP [p97] and p47 complex interacting protein, p135) functions as a deubiquitinating enzyme whose activity is required for post-mitotic Golgi reassembly 26."
29225785
biogrid
No evidence text available
18775313
biogrid
No evidence text available
19615732
reach
"We have shown that VCIP135 binds to syntaxin5 and disassembles the p97, p47, and syntaxin5 complex through p97 ATP hydrolysis."
12473691
reach
"During late mitosis, VCIP135 becomes dephosphorylated and associates with the p97, p47, and Syn5 complex."
28819009
sparser
"As ATPases, NSF and p97 have specific co-factors: NSF-mediated fusion requires the proteins SNAPs and p115, while the p97-mediated pathway requires formation of a complex with p47 and VCIP135, or with p37 (Kondo et al., xref ; Uchiyama et al., xref )."
26734607
biogrid
No evidence text available
12473691
reach
"VCIP135 binds to the p97, p47, and syntaxin-5 complex and can dissociate p97 and p47 from syntaxin-5."
15037600
biogrid
No evidence text available
26389662