IndraLab

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USP7 inhibits DNMT1. 4 / 5
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"Expression of shRNA resistant wild-type Usp7 in Usp7 depleted cells reduced the size of Dnmt1 nuclear foci, but catalytically-inactive Usp7 (C223S) failed to do so."
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"Loss of USP7 enhances DNMT1 association with replication sites As increased histone ubiquitination is observed in USP7 KO cells , we next examined if loss of USP7 results in an increase of DNMT1 recruitment in S phase of cell cycle ."
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"Furthermore, loss of HAUSP combined with inhibition of HDAC activity had a synergistic effect on DNMT1 protein stability, because treatment of HAUSP knockout cells with various HDAC inhibitors reduced DNMT1 abundance to nearly undetectable amounts (XREF_FIG and XREF_SUPPLEMENTARY)."
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"Thus , consistent with an increased DNA methylation phenotype , loss of USP7 apparently enhanced DNMT1 association with replicating DNA , a result consistent with a previous study44 ."
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