IndraLab

Statements

COPS5 inhibits NEDD8. 4 / 4
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"In particular, CSN inhibition of CRL4 DDB2 is non enzymatic, independent of CSN5 mediated cleavage of ubiquitin like protein Nedd8, whose conjugation to Cullins activates Cullin based ubiquitin ligase."
27696486
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"Indeed, conditional silencing of CSN5 in HEK293 cells increased the neddylation of cullins."
22655267
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"Constitutive photomorphogenesis 9 (COP9) signalosome 5 (CSN5), an isopeptidase that removes neural precursor cell expressed, developmentally down-regulated 8 (NEDD8) moieties from cullins (thus termed " deNEDDylase ") and a subunit of the cullin RING E3 ligase regulating COP9 signalosome complex, attenuates proinflammatory NF-kappaB signaling."
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"CSN5 is responsible for the cleavage of NEDD8 from CRLs, and blocking deconjugation of NEDD8 traps the CRLs in a hyperactive state, thereby leading to auto-ubiquitination and ultimately degradation of the substrate recognition subunits."
27981705