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PDE4B decreases the amount of CYLD. 6 / 6
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"In the present study, we identified PDE4B as a key negative regulator for CYLD via selective activation of c-jun N-terminal kinase 2 (JNK2), but not JNK1, and inhibition of PDE4B significantly enhanced NTHi induced CYLD expression and suppressed inflammation."
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"In the present study, we showed that inhibition of PDE4B markedly enhanced upregulation of CYLD expression by the bacterial pathogen NTHi, thereby suggesting that PDE4B acts as a negative regulator for CYLD."
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"Inhibition of PDE4B markedly increased the expression of CYLD and subsequently suppressed bacteria induced inflammation in well established models of both lung and middle ear inflammation."
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"As shown in XREF_FIG, PDE4B knockdown selectively inhibited activation of JNK2 but not JNK1, thereby confirming that PDE4B negatively regulates NTHi induced CYLD expression and mediates inflammation via specific activation of JNK2 but not JNK1."
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"These results suggest that PDE4B negatively regulates CYLD expression and mediates inflammation via the JNK pathway."
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"Taken together, it is evident that PDE4B negatively regulates CYLD expression and mediates NTHi induced inflammation via specific activation of JNK2 but not JNK1 pathway."
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