IndraLab

Statements

GMPS activates USP7. 22 / 23
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"In our assays, USP7 activation by GMPS was not directly coupled to the GMP synthesis reaction."
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"Activation of USP7 by GMPS against a minimal substrate changes only k cat."
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"Intriguingly, allosteric activation of USP7 by GMPS (guanine monophosphate synthase) that stabilises alignment of the catalytic site can also direct USP7 activity towards p53 under genotoxic stress [XREF_BIBR, XREF_BIBR]."
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"Thus, USP7 activation by GMPS appeared not to be directly coupled to the GMP synthesis reaction in our assays."
15749019
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"Interestingly, upon interaction with the CTD of USP7, guanine monophosphate synthetase (GMPS) is able to allosterically activate USP7 and increase the efficiency of its catalytic activity ( van der Kn[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"For example, USP1, USP12, and USP46 are activated by the WD40-repeat containing UAF1, and USP7 is activated by GMPS (Cohn et al., 2007, 2009; Faesen et al., 2011; van der Knaap et al., 2005)."
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"GMPS activates USP7 through an allosteric mechanism, which is independent of its GMP synthesis function ( xref , xref ; xref )."
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"Therefore, this suggests that for some USPs the KG FP reagent may be a better substrate, and provide more relevant kinetic parameters.This study confirmed that the modulator UAF1 activates USP1, USP12[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"A USP7 cofactor called GMPS that strongly augments USP7 activity was recently identified in Drosophila (van der Knaap et al., 2005)."
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"How can GMPS stimulate the deubiquitylation activity of USP7?"
15749019
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"In our assays, USP7 activation by GMPS was not directly coupled to the GMP synthesis reaction."
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"The GMP synthetase (GMPS) was found to interact with and stimulate USP7 activity through its binding to the first three UBLs in USP7 (HUBL-123) and promote an " on-state " in USP7."
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"GMPS activates USP7 through an allosteric mechanism, which is independent of its GMP synthesis function (van der Knaap et al. 2005, 2010; Faesen et al. 2011)."
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"GMPS is an allosteric activator of USP7 and stabilizes its active state resulting in hyperactivation of USP7 54."
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"Intriguingly, allosteric activation of USP7 by GMPS (guanine monophosphate synthase) that stabilises alignment of the catalytic site can also direct USP7 activity towards p53 under genotoxic stress [ xref , xref ]."
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"A new structural and biophysical study clarified how GMPS activates USP7 [ 25 •• ]."
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"Activation of USP7 by GMPS against a minimal substrate changes only k cat ( xref )."
25702870
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"Thus, USP7 activation by GMPS appeared not to be directly coupled to the GMP synthesis reaction in our assays."
15749019
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"This shows that GMPS can allosterically activate USP7 by binding to HUBL-123, stabilizing the contact between HUBL-45 and USP7CD, thus promoting the activated state.We show here that the C-terminal HU[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"However, we show that binding of GMPS can further activate USP7."
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"It has been reported that the metabolic enzyme GMP synthetase can promote USP7 activity through an allosteric mechanism requiring binding to the USP7 C-terminal tail [45] ."
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"The parallels between GMPS and ICP0 binding to USP7 raise the possibilities that ICP0 might mimic GMPS in stimulating USP7 activity or alternatively that it might interfere with GMPS stimulation of USP7 activity by competing with GMPS for USP7."
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