IndraLab

Statements

GMPS activates USP7. 17 / 18
| 13 4
reach
"Therefore, this suggests that for some USPs the KG FP reagent may be a better substrate, and provide more relevant kinetic parameters.This study confirmed that the modulator UAF1 activates USP1, USP12[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22195557
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"The parallels between GMPS and ICP0 binding to USP7 raise the possibilities that ICP0 might mimic GMPS in stimulating USP7 activity or alternatively that it might interfere with GMPS stimulation of USP7 activity by competing with GMPS for USP7."
26046769
reach
"For example, USP1, USP12, and USP46 are activated by the WD40-repeat containing UAF1, and USP7 is activated by GMPS (Cohn et al., 2007, 2009; Faesen et al., 2011; van der Knaap et al., 2005)."
22195557
reach
"However, we show that binding of GMPS can further activate USP7."
21981925
reach
"The GMP synthetase (GMPS) was found to interact with and stimulate USP7 activity through its binding to the first three UBLs in USP7 (HUBL-123) and promote an " on-state " in USP7."
23116119
sparser
"Intriguingly, allosteric activation of USP7 by GMPS (guanine monophosphate synthase) that stabilises alignment of the catalytic site can also direct USP7 activity towards p53 under genotoxic stress [ xref , xref ]."
28900014
reach
"Activation of USP7 by GMPS against a minimal substrate changes only k cat."
25702870
reach
"GMPS is an allosteric activator of USP7 and stabilizes its active state resulting in hyperactivation of USP7 54."
29657328
sparser
"Activation of USP7 by GMPS against a minimal substrate changes only k cat ( xref )."
25702870
reach
"This shows that GMPS can allosterically activate USP7 by binding to HUBL-123, stabilizing the contact between HUBL-45 and USP7CD, thus promoting the activated state.We show here that the C-terminal HU[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21981925
reach
"A USP7 cofactor called GMPS that strongly augments USP7 activity was recently identified in Drosophila (van der Knaap et al., 2005)."
16325574
reach
"In our assays, USP7 activation by GMPS was not directly coupled to the GMP synthesis reaction."
15749019
sparser
"Thus, USP7 activation by GMPS appeared not to be directly coupled to the GMP synthesis reaction in our assays."
15749019
sparser
"In our assays, USP7 activation by GMPS was not directly coupled to the GMP synthesis reaction."
15749019
reach
"Intriguingly, allosteric activation of USP7 by GMPS (guanine monophosphate synthase) that stabilises alignment of the catalytic site can also direct USP7 activity towards p53 under genotoxic stress [XREF_BIBR, XREF_BIBR]."
28900014
reach
"Thus, USP7 activation by GMPS appeared not to be directly coupled to the GMP synthesis reaction in our assays."
15749019
reach
"How can GMPS stimulate the deubiquitylation activity of USP7?"
15749019