IndraLab

Statements

PSMD14 activates SARS-CoV-2. 2 / 2
| 2
reach
"Next, we investigated whether POH1 modulated the maturation and release of native SARS-CoV-2."
35100873
reach
"All together, these data revealed a previously undescribed mechanism by which RNF5 and POH1 mediate the ubiquitin modification of SARS-CoV-2 M for virion trafficking and release.As noted by previous studies, unlike with most enveloped viruses, in which M is necessary and sufficient to mediate VLP release, the E/M proteins of murine hepatitis virus (MHV) or the M/E/N proteins of SARS-CoV are necessary for efficient assembly, trafficking, and VLP release (7–9)."
35100873