IndraLab

Statements

BAP1 inhibits Multiple Myeloma. 7 / 7
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"Loss of BAP1 is frequently observed in MM and has been proven to increase the risk of MM [XREF_BIBR - XREF_BIBR]."
28978163
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"Transduction of the WT BAP1 vector inhibited cell proliferation of the Y-MESO-25 MM cell line with BAP1 deletion by approximately 50% compared to the cells with control vector (GFP)."
26011428
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"Our results suggested that, whereas WT BAP1 suppresses MM cell proliferation and restores cell survival after IR damage, some mutant BAP1 may also moderately retain these functions."
26011428
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"BAP1 suppresses MM cell proliferation."
26011428
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"In effusions with mesotheliomatous cells or atypical mesothelial cells of uncertain significance, negative BAP1 IHC strongly supports a diagnosis of MM."
28994508
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"Bap1 deletion alone does not cause MM but dramatically accelerates MM development when combined with Nf2 and Cdkn2ab (hereafter BNC) disruption."
32271879
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"With the colony formation assay, we also found that WT BAP1 suppressed the anchorage independent cell growth of the MM cells with BAP1 deletion, whereas mutant BAP1 showed little or no reduced effect."
26011428