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UCHL5 leads to the dephosphorylation of SMAD2. 2 / 2
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"We investigated whether a similar mechanism occurs in extravillous trophoblasts and found that bAP15, an inhibitor of UCHL5, negatively regulates the phosphorylation of Smad2 in a concentration-dependent manner."

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"Beyond that, dephosphorylation of Smad2 could also be mediated by UCHL5, which plays a crucial role in suppressing cell apoptosis and sustaining cell survival [XREF_BIBR]."