IndraLab

Statements

PKA phosphorylates CACNA1C. 3 / 4
| 3
sparser
"Some of the cardinal debated issues include details of specific subunits and residues in CaV1.2 phosphorylated by PKA, the nature, extent, and role of post-translational processing of CaV1.2, and the role of auxiliary proteins (such as A kinase anchoring proteins) involved in PKA regulation."
23948586
sparser
"Phosphorylation of Cav1.2 by protein kinase A promotes the opening of L-type calcium channels in cardiac muscle; therefore, Cav1.2 is a major target of the sympathetic nervous system in the heart [134]."
33530560
sparser
"The α1C subunit is phosphorylated by PKA in intact hippocampal neurons, and a two-fold increase in Ca 2+ influx has been observed in hippocampal neurons in old rats compared with adult rats, suggestive of increased PKA phosphorylation of Cav1.2 with aging."
35111050