IndraLab

Statements

USP25 inhibits Interferon. 12 / 12
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"However, the catalytic mutants (C178A and H607A) devoid of DUB activity lost the ability of USP25 WT mediated IFN inhibition to some degree, indicating that DUB activity is involved in USP25 inhibition of type I IFN induction."
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"To further determine the levels at which USP25 negatively regulates type I IFN signaling, HEK-293T cells were transfected with DNA constructs encoding RIG-I, IPS-1, TRAF2, or TRAF6, together with IFN-beta-Luc."
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"Several studies showed that USP25 negatively regulates virus-induced type I IFN signaling by stabilizing TRAF2, TRAF3 and TRAF6 [64,65,75,87,121,122,123,124]."
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"In addition, the catalytic USP25 mutants (C178A and H607A) devoid of DUB activity significantly lost the ability of USP25 WT mediated IFN inhibition."
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"Future investigation will be required to test whether these domains of USP25 are also involved in USP25 mediated IFN inhibition."
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"For example, in HSV-1 infection, where USP21 mediates negative regulation of Type I interferon through the deubiquitination of STING 72, UL46 can both bind the N-terminus of STING 73 and inhibit the dimerization of TBK1 74 to deregulate the pathway."
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"We further investigated the effect of USP25 knockdown on virus triggered IFN signaling."
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"Collectively, these findings suggest that USP25 inhibits RIG-I and MDA5-dependent type I IFN signaling."
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"USP25 inhibits SEV induced type I IFN signaling by disrupting activation of IRF3 and NF-kappaB."
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"In addition, USP25 deficiency inhibits transcriptional activity of interferon regulatory factor, thereby reducing type I interferon production."
| PMC
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"To examine whether the inhibitory effects of USP25 on SEV induced type I IFN signaling is due to its deubiquitinase activity, wild-type USP25 (USP25-WT) and its mutants (C178A and H607A) lacking DUB activity were co-transfected with the promoter luciferase reporter plasmid of IFN-beta, IRF3, NF-kappaB and ISRE, and the luciferase activity was detected."
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"Interestingly, the genetic deletion of USP21 in macrophages enhances IRF3 activation, IFN production, and antiviral response."
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