IndraLab

Statements

EGFR activates IRS1. 4 / 4
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"Moreover, inhibition of PKA and CAMKII decreased EGF-induced activation of EGFR and AKT and heregulin-induced activation of Her3, IRS1, and AKT."
36332175
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"Since Pak1 signaling is also affected EGFR and Akt (a target of IRS1), we next examined the levels of EGFR and IRS-1 proteins in the cell lysates used above in this study."
18922890
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"A potential explanation for these results is provided by in vitro data demonstrating that IRS-1 can be targeted by the EGFR."
20670944
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"The results of their study demonstrated that miRNA-7 directly suppresses EGFR and upstream modulators of the IGF-1R/Akt signaling pathway, IRS-1 and IRS-2 proteins.Further studies have shown that miRNA-7 has the potential to enhance the sensitivity of the cancer cells to the various therapies."
32592373