IndraLab

Statements

TRIM25 binds USP15. 20 / 22
4 | 9 7
sparser
"USP15 binds to TRIM25 in viral infections, detaching the K48-linked ubiquitin chains assembled by LUBAC on TRIM25, thereby stabilizing the TRIM25 protein levels and promoting a sustained antiviral response (Figure xref )."
29018447
biogrid
No evidence text available
24399297
reach
"USP15 bound to TRIM25 specifically late during infection, removing Lys48 linked ubiquitin chains from TRIM25 and thus stabilizing it XREF_BIBR."
25023063
sparser
"Torre et al. validated a functional interaction of a complex of USP15 with TRIM25 in neuroinflammation by showing ECM resistance in double heterozygous Usp15 L749R/+ Trim25 +/− mice."
27984564
sparser
"Interestingly, it has been shown that HPV16 E6, but not E7, forms a complex with TRIM25 and its regulator ubiquitin carboxyl-terminal hydrolase 15 (USP15), inducing TRIM25 degradation [ xref ]."
32164347
reach
"For instance, USP15 interacts with and deubiquitinates TRIM25 when it is ubiquitinated by the E3 complex LUBAC."
25651846
reach
"USP15 physically interacts with TRIM25."
24399297
reach
"We first confirmed the physical interaction between TRIM25 and USP15 with coimmunoprecipitation experiments."
24399297
reach
"In contrast, USP15 substantially interacted with TRIM25 at later time points during SeV infection."
24399297
reach
"Consistently, there was increased binding of USP15 to TRIM25 in infected primary normal human lung fibroblasts (NHLFs), whereas the interaction was minimal in uninfected cells (XREF_SUPPLEMENTARY)."
24399297
reach
"Furthermore, whereas our results showed that USP15 efficiently interacted with TRIM25 specifically in infected cells, USP4 constitutively interacts with RIG-I."
24399297
sparser
"The E6 oncoprotein of HPV16 interacts with TRIM25 and USP15, promoting K48-linked ubiquitination of TRIM25 and suppressing TRIM25-mediated K63-linked ubiquitination of RIG-I to evade the host antiviral response ( xref )."
34925304
biogrid
No evidence text available
24399297
biogrid
No evidence text available
24399297
biogrid
No evidence text available
24399297
reach
"USP15 binds to TRIM25 in viral infections, detaching the K48 linked ubiquitin chains assembled by LUBAC on TRIM25, thereby stabilizing the TRIM25 protein levels and promoting a sustained antiviral response."
29018447
sparser
"Furthermore, HPV E6 protein forms a ternary complex with USP15 and TRIM25, resulting in the inhibition of immune surveillance and antiviral responses, thereby exhibiting a direct involvement in immune system regulation [ xref ]."
32085533
sparser
"USP15 bound to TRIM25 specifically late during infection, removing Lys48-linked ubiquitin chains from TRIM25 and thus stabilizing it xref ."
25023063
sparser
"In the RLR-mediated signaling pathway, E6 forms a three-molecule complex with TRIM25 and USP15, which triggers the K48-linked ubiquitination and proteasomal degradation of TRIM25, attenuates the TRIM25-mediated K63-linked ubiquitination of RIG-I."
34966378
reach
"Instead, coimmunoprecipitation and confocal microscopy studies indicated that USP15 efficiently bound to TRIM25 in virus infected cells, whereas, in contrast, a TRIM25-USP15 interaction was barely detectable in un infected cells."
24399297