IndraLab

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Radiation, Ionizing activates KCNMA1. 13 / 13
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"Thereby, IR induced BK channel activity seemed to be a key event since BK blockage by paxilline abrogated IR induced brain infiltration."
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"Huber and coworkers first showed, in an in vitro study, that IR-induced BK channel activation is a key event in IR-induced GBM migration, and that the BK channel blocker paxilline suppresses it [ xref ]."
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"These results suggest that the previously reported IR induced and paxilline sensitive migration of T98G cells [XREF_BIBR] is mediated by IR induced BK channel activation."
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"The BK inhibitor paxilline blocked the IR-induced outward current (Figure xref , grey closed triangles and Figure xref , 4th bar) and the paxilline-sensitive current fraction showed typical outward rectification (Figure xref , closed triangles) indicative of IR-induced BK channel activation."
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"These results suggest that the previously reported IR-induced and paxilline-sensitive migration of T98G cells [ xref ] is mediated by IR-induced BK channel activation."
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"Likewise, AMD3100 significantly blocked the BK channel activation by IR when applied before on-cell patch-clamp recording (Figure xref , xref )."
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"Therefore, U-87MG-Katushka and T98G were tested in vitro for IR induced BK channel activity, transfilter migration and the role of SDF-1 signaling herein in order to define radiation induced signaling events upstream of BK channel activation."
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"Together, these data indicate radiation induced migration in U-87MG-Katushka cells depending on IR induced BK channel activity."
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"The BK inhibitor paxilline blocked the IR induced outward current and the paxilline sensitive current fraction showed typical outward rectification indicative of IR induced BK channel activation."
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"Huber and coworkers first showed, in an in vitro study, that IR-induced BK channel activation is a key event in IR-induced GBM migration, and that the BK channel blocker paxilline suppresses it [86]."
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"Together, these data suggest the involvement of SDF-1 and CXCR4 signaling in IR induced BK channel activation of U-87MG-Katushka cells."
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"Based on these data, these authors concluded that IR stimulates BK channel activity which results in activation of CaMKII leading to enhanced cell migration."
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"To test, whether SDF-1 can mimic IR induced BK channel activation and migration in U-87MG-Katushka cells, free [Ca 2+] i was recorded during wash-in of SDF-1."
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