IndraLab

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NGF bound to NTRK1 activates cell differentiation. 11 / 11
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"The specific binding of NGF and TrkA promotes the neuronal differentiation and cell survival via multiple signal cascades, such as Ras-MEK1/2-ERK1/2, PI3K-Akt, and phospholipase C-γ1 (PLCγ1) pathways [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"For example, while binding of NGF to TrkA receptors or to TrkA and p75 heteromers leads to cell survival and differentiation, binding of NGF to p75 leads to apoptosis in most cell types (Yan et al., 2[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"For example, in PC12 cells, EGF stimulation of EGFR leads to transient Erk phosphorylation and cell proliferation, whereas NGF binding to TrkA leads to sustained Erk phosphorylation and cell differentiation."
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"NGF binds specifically to trkA and activates downstream signaling pathways, including MAPK/ERK and PI3K/Akt cascades to promote neuronal differentiation and survival [ 48 ]."
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"The binding of NGF to TrkA promotes growth, differentiation and survival of several neural cells [11–13] ."
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"NGF binds to TrkA, activates the intrinsic kinase activity of TrkA, and promotes the differentiation of pheochromocytoma (PC12) cells into sympathetic like neurons."
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"NGF binding to its protein kinase receptor TrkA is known to induce neurite outgrowth and neural cell differentiation."
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"Extracellular ligand NGF binds NTRK1 and NGFR receptors and activates cellular signaling cascades to regulate neuronal proliferation, differentiation, and survival."
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"Similar mechanisms promoting tumoral cell survival or counteracting neuronal differentiation may be also involved in NB where NGF and TrkA interaction induced differentiation of tumour cells (Eggert et al, 2000)."
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"Several lines of evidence underline that the binding of NGF to TrkA receptor mediates proliferation, differentiation and survival of both neurons and cancer cells via the activation of PI3K/Akt, Ras/MAPK and PLCγ pathways [10]."
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"NGF binds to TrkA receptors and induces differentiation into sympathetic ganglia."
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