IndraLab

Statements

NGF bound to NTRK1 activates cell differentiation. 6 / 6
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"NGF binding to its protein kinase receptor TrkA is known to induce neurite outgrowth and neural cell differentiation."
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"For example, while binding of NGF to TrkA receptors or to TrkA and p75 heteromers leads to cell survival and differentiation, binding of NGF to p75 leads to apoptosis in most cell types (Yan et al., 2[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"NGF binds to TrkA, activates the intrinsic kinase activity of TrkA, and promotes the differentiation of pheochromocytoma (PC12) cells into sympathetic like neurons."
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"Similar mechanisms promoting tumoral cell survival or counteracting neuronal differentiation may be also involved in NB where NGF and TrkA interaction induced differentiation of tumour cells (Eggert et al, 2000)."
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"NGF binds to TrkA receptors and induces differentiation into sympathetic ganglia."
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"For example, in PC12 cells, EGF stimulation of EGFR leads to transient Erk phosphorylation and cell proliferation, whereas NGF binding to TrkA leads to sustained Erk phosphorylation and cell differentiation."
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