IndraLab

Statements

AKT phosphorylates GSK3 at position 9. 8 / 8
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"DCT induced PI3K and Akt activation resulted in downstream phosphorylation of GSK-3 (Ser (21/9)) and BAD (Ser (136)), and nuclear translocation (activation) of NF-kappaB, thereby confirming that DCT induced activation of PI3K and Akt signaling regulates both proproliferative and prosurvival signals."
18064605
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"AKT phosphorylates GSK3 on serine 9 for GSK3beta or 21 for GSK3alpha, thereby inactivating GSK3 XREF_BIBR."
23077590
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"Serine 9 of GSK3β can be phosphorylated by AKT and other kinases , leading to GSK-3β inactivation."
32528070
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"In response to insulin binding, PKB and AKT phosphorylates GSK-3 on serine 9, which prevents the enzyme from phosphorylating glycogen synthase [XREF_BIBR - XREF_BIBR]."
22493531
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"Akt phosphorylates GSK-3 at Serine 21 and Serine 9 in two different isoforms GSK-3 and GSK-3 respectively and inhibits its activity [XREF_BIBR, XREF_BIBR]."
27245276
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"In response to insulin binding, PKB and AKT phosphorylates GSK-3 on serine 9, which prevents the enzyme from phosphorylating glycogen synthase [XREF_BIBR]."
25885803
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"Both insulin and IGF-1 activate Akt which phosphorylates serine 9 on GSK3β resulting in its inhibition [33, 34]."
31707362
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"However, activated AKT (P-Ser473) usually phosphorylates GSK3β at serine 9, thereby causing inactivation of the protein (reviewed in [3])."
34626204