Other Services

This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

SCN2A decreases the amount of PrP Sc. 2 / 2

| 2

➶

reach

"Surprisingly, exposure of ScN2a cells (i.e. chronically prion infected N2a cells) to tau K18 fibrils, reduced PrP Sc levels and increased PrP C alpha-cleavage [XREF_BIBR]."

33345731

➶

reach

"To determine the ASO 771 concentration at which PrP C and PrP Sc levels were suppressed by 50% (half maximal effective concentration (EC 50)) in N2a and ScN2a cells, we treated cells with ASO 771 at concentrations ranging from 2 to 250nmol/l, collected lysates after 7 days, then measured PrP C and PrP Sc levels by western blot."

23344724

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...