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SCN2A decreases the amount of PrP Sc. 3 / 3
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"To determine the ASO 771 concentration at which PrP C and PrP Sc levels were suppressed by 50% (half maximal effective concentration (EC 50)) in N2a and ScN2a cells, we treated cells with ASO 771 at concentrations ranging from 2 to 250nmol/l, collected lysates after 7 days, then measured PrP C and PrP Sc levels by western blot."
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"Time course experiments showed that PrP Sc levels were reduced by P2 for ScN2a lysate, P3 for Chandler prion-infected brain homogenate, and P4 for Obihiro prion-infected brain homogenate and remained [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Surprisingly, exposure of ScN2a cells (i.e. chronically prion infected N2a cells) to tau K18 fibrils, reduced PrP Sc levels and increased PrP C alpha-cleavage [XREF_BIBR]."
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