IndraLab

Statements

UCHL1 activates hydrolase. 3 / 3
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"Besides TGFbeta blockade, interesting results were shown using LDN57444, a specific small molecule inhibitor, targeting ubiquitin carboxy-terminal hydrolase L1 (UCH-L1)."
28771186
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"The major findings of this study are (1) CyPGs such as 15dPGJ2 adduct the C152 of UCH-L1 and mutation of the C152 of UCH-L1 attenuates the loss of hydrolase activity after 15dPGJ2 treatment; (2) the UCH-L1 C152A mutation decreases 15dPGJ2 induced accumulation and aggregation of UCH-L1 and ubiquitinated proteins in primary neurons; and (3) primary neurons derived from UCH-L1-C152A mutant mice are resistant to cell death and neurite injury induced by treatment with 15dPGJ2."
26539913
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"To answer these questions of morphogenesis, developing CVP and VEG were examined using the pan-neuronal antibody, PGP9.5, directed against ubiquitin carboxyl terminal hydrolase."
22254156