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UCHL1 activates hydrolase. 7 / 7
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"To answer these questions of morphogenesis, developing CVP and VEG were examined using the pan-neuronal antibody, PGP9.5, directed against ubiquitin carboxyl terminal hydrolase."
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"We have previously reported that the S18Y substitution in UCH-L1 potentiates its hydrolase activity to 113% of the normal level ( Nishikawa et al., 2003 )."
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"Recently, Kabuta et al. found that UCHL1 enhances the activities of cyclin-dependent kinases to enhance cell proliferation independently of its hydrolase activity [15] ."
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"Here, we analyzed subchondral bone samples from OA patients and observed a significant upregulation of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) specifically in subchondral bone osteoclasts."
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"Furthermore, UCH-L1 over-expression increased the protein/gDNA ratio, whereas stable UCH-L1 knockdown or inhibition of UCH-L1 hydrolase function decreased the protein/gDNA ratio in cultured podocytes [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Besides TGFbeta blockade, interesting results were shown using LDN57444, a specific small molecule inhibitor, targeting ubiquitin carboxy-terminal hydrolase L1 (UCH-L1)."
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"The major findings of this study are (1) CyPGs such as 15dPGJ2 adduct the C152 of UCH-L1 and mutation of the C152 of UCH-L1 attenuates the loss of hydrolase activity after 15dPGJ2 treatment; (2) the UCH-L1 C152A mutation decreases 15dPGJ2 induced accumulation and aggregation of UCH-L1 and ubiquitinated proteins in primary neurons; and (3) primary neurons derived from UCH-L1-C152A mutant mice are resistant to cell death and neurite injury induced by treatment with 15dPGJ2."
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