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IGF1R activates IRS1. 42 / 44
10 | 1 27 4
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"Clemmons et al. have shown that, under normoglycemic conditions, stimulation of the IGF-IR expressed on vascular smooth muscle cells and vascular endothelial cells only activates IRS-1 leading to stimulation of the " metabolic " (phosphoinositide 3) PI-3 kinase pathway, but not to stimulation of the " mitogenic " (mitogen activated protein) MAP kinase pathway."
24904529
reach
"The knock-down of ARID1A increased IGF-1R levels, prevented IGF-1R and IRS1 suppression upon Bex+Carv and stimulated proliferation."
35320351
signor
"Binding of IGF1 to its receptor leads to activation of its intrinsic tyrosine kinase and autophosphorylation, thus generating docking sites for insulin receptor substrate (IRS), which is also phosphorylated by the IGF1 receptor."
21798082
sparser
"This review discusses recently published data regarding the ability of hyperglycemia to sensitize cells that are capable of dedifferentiating to the growth promoting effects of IGF-I. Under normoglycemic conditions vascular smooth muscle and endothelial cells are cystostatic and stimulation of the IGF-I receptor activates the adaptor protein IRS-1 which leads to PI-3 kinase pathway activation."
21707534
signor
"Furthermore, IGF-1 stimulates tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) and IRS-2 and their association with the p85 subunit of phosphoinositide-3 kinase (PI3K)."
17827393
signor
"IGF-I binding to its receptor activates the kinase activity of the receptor, which then recruits the insulin response substrate-1, causing activation of phosphatidyl-inositol-3 kinase (PI3K) to phosphorylate Akt."
15829723
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"The inhibition of IGF-IR by siRNA and PPP downregulated pIRS-1, pAKT, and pSTAT3 and induced caspase-3 cleavage in MCL."
27661006
signor
"Furthermore, IGF-1 stimulates tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) and IRS-2 and their association with the p85 subunit of phosphoinositide-3 kinase (PI3K)."
17827393
signor
"Furthermore, IGF-1 stimulates tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) and IRS-2 and their association with the p85 subunit of phosphoinositide-3 kinase (PI3K)."
17827393
sparser
"Another study from the same group [ xref ] established that phosphorylation of AKT on Thr308 and Ser473 increases following treatment of ALL cells with AICAR and demonstrated that AKT phosphorylation on Thr 308 is mediated by AMPK-induced IGF-1R activation and phosphorylation of IRS-1."
22249159
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"Expression of mediators of IGF1R signalling and phosphorylation status of IRS1 was determined in chondrosarcoma cell lines by qRT-PCR and western blot."
27418340
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"Recently, we demonstrated that IGF-1R kinase inhibitor PQIP causes marked antitumor activity in these colon cancer cell lines by abrogating the IGF-1R mediated activation of IRS1 and Akt to inhibit survival signaling, and inducing apoptosis."
24173770
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"Moreover, the decrease of IGF1R impairs the sensitivity of IRS1 to the stimulation by IGF1."
21616916
reach
"IRS-1, especially when activated by the IGF-IR, sends an unambiguously mitogenic, anti-apoptotic and anti-differentiation signal [9]."
18851963
reach
"Similarly, mammalian target of rapamycin (m-TOR) inhibitors can activate PI3K-Akt pathway via loss of negative feedback on IRS-1 (insulin receptor substrate -- 1), an effect that can be suppressed by IGF-1R blockade [XREF_BIBR - XREF_BIBR]."
22415797
reach
"Under normoglycemic conditions vascular smooth muscle and endothelial cells are cystostatic and stimulation of the IGF-I receptor activates the adaptor protein IRS-1 which leads to PI-3 kinase pathway activation."
21707534
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"These cells lack IRS-1 and -2 expression, yet express functional IGF-IR, allowing us to investigate whether IGF-IR activation stimulates cell proliferation and motility in the absence of IRS-1 and -2."
17043687
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"Tyrosine phosphorylation of IGF-1R upon extracellular ligand binding induces the activation of insulin receptor substrate 1 that can provide sufficient binding of initial effector associated tyrosine phosphorylation genes with an SH2-domain, such as PI3K, Shc and Grb2, through pleckstrin homology and phosphotyrosine binding domains XREF_BIBR, XREF_BIBR."
29712908
signor
"Furthermore, IGF-1 stimulates tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) and IRS-2 and their association with the p85 subunit of phosphoinositide-3 kinase (PI3K)."
17827393
eidos
"These results suggested that the decreases in IRS-1 and IGF signaling by IGF-I receptor downregulation could be crucial for cell differentiation ."
32180762
reach
"In support of this hypothesis, we report here that : (1) IRS-1 expression increases cell adhesion and decreases cell motility; (2) over-expression of the IGF-IR, in the absence of IRS-1, causes growth arrest and (3) a combination of IGF-IR and IRS-1 restores the transformed phenotype of LNCaP cells."
10851068
reach
"Moreover, a dynamic interplay between IGF and ERalpha in breast cancer cells has been demonstrated, where IGF-1R increase ERalpha phosphorylation and activity via mTOR and S6K1 and ERalpha mediates IGF-1R, IRS-1 and IGF ligand expression [XREF_BIBR]."
27765027
reach
"To investigate the roles of TGFbeta and IGF signaling pathways in miR-130a and miR-145 regulations of myeloid immune function, overexpression constructs of Tgfbr2, Igf1r, and Irs1 without 3 '-UTR were utilized to prevent the mRNA degradation of TbetaRII, IGF1R and IRS1 in Gr-1 + CD11b + cells by miR-130a or miR-145."
29973593
reach
"Inhibiting IGF1R in conjunction with mTORC1 inhibition should abrogate this feedback activation of IRS1, potentially leading to more effective antitumor activity."
28324268
sparser
"While tyrosine-phosphorylated IRS-1 is activated by IGF-IR, phosphorylation of IRS-1 on serine/threonine by multiple kinases including JNK [37] , IKK [38] , Rho Kinase [39] , PKC ξ [40] and PI3K/[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
16297654
reach
"In cancer cells, IGF-1R activates IRS-1 by stimulating several intracellular signaling proteins such as PI3K and Akt kinase."
24970012
reach
"This study further suggested that phosphorylation of Ob-R and IGF-IR subsequently activated downstream signaling molecules Akt, ERK, IRS-1, and IRS-2."
22289780
reach
"IGF-1 exerts its physiologic effects by binding to the IGF-1 receptor (IGF-1R), which initiates the IRS-1, PI3K, and MAPK pathway and activates ERK to promote cell proliferation and survival [34]."
29707570
signor
"Furthermore, IGF-1 stimulates tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) and IRS-2 and their association with the p85 subunit of phosphoinositide-3 kinase (PI3K)."
17827393
signor
"Furthermore, IGF-1 stimulates tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) and IRS-2 and their association with the p85 subunit of phosphoinositide-3 kinase (PI3K)."
17827393
reach
"The reasons why Gab1 and IRS1 signaling is caused by increased IGF-1R phosphorylation via FOXA1 by osimertinib exposure but not baseline IGF-1R phosphorylation remains to be elucidated."
32929081
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"Activation of the IGF-1R causes sequential activation IRS-1, which in turn activates the PI3K and Akt pathway, resulting in activation of mTOR, which is involved in protein synthesis and cell growth XREF_BIBR."
31205529
signor
"Furthermore, IGF-1 stimulates tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) and IRS-2 and their association with the p85 subunit of phosphoinositide-3 kinase (PI3K)."
17827393
reach
"Inhibition of IGF-IR signaling disrupted the association of IRS-1 with PI3K and restored the ability of gefitinib to down-regulate PI3K and AKT signaling and to inhibit cell growth."
26579470
reach
"This compensatory mechanism promotes cell survival because inhibition of IGF-1R activity in either presence or absence of AICAR decreases P-IRS-1 (Ser794) and P-Akt (Thr308) levels and significantly increases apoptotic cell death."
20863384
sparser
"In cancer cells, IGF-1R activates IRS-1 by stimulating several intracellular signaling proteins such as PI3K and Akt kinase ( xref – xref )."
24970012
signor
"Furthermore, IGF-1 stimulates tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) and IRS-2 and their association with the p85 subunit of phosphoinositide-3 kinase (PI3K)."
17827393
reach
"IGF-1 and IGF-1R induces differentiation rather than proliferation when the cells do not express or underexpress insulin receptor substrate-1 (IRS-1), a docking protein for both IGF-1R and the insulin receptor that is known to send a mitogenic, anti-apoptotic and anti-differentiation signal XREF_BIBR XREF_BIBR."
23403580
reach
"These results suggested that the decreases in IRS-1 and IGF signaling by IGF-I receptor downregulation could be crucial for cell differentiation.L6 myoblasts that highly expressed IRS-1 protein were eliminated from the cell layer upon culturing with normal cells due to sustained activation of the IGF-I receptor on the plasma membrane."
32180762
reach
"IRS1 activated by IGF-IR recruits intracellular proteins containing SH2 domains, leading to activation of the PI3K-AKT, which is responsible for most of the metabolic actions of insulin, FOXO1 pathways [XREF_BIBR]."
27213336
reach
"Activation of IGF-IR results in intrinsic tyrosine kinase phosphorylation and activates downstream adaptor protein IRS-1 and Shc, leading to activation of IRS-1/PI3K/Akt [XREF_BIBR]."
28137302
reach
"Ligand activation of IGF-IR results in intrinsic tyrosine kinase phosphorylation and activates downstream adaptor protein IRS-1 and Shc, leading to activation of two main signaling pathways, IRS-1/PI3K/Akt and Ras/Raf/ERK pathways respectively [XREF_BIBR - XREF_BIBR]."
28137302