IndraLab

Statements

Spautin-1 inhibits USP10. 10 / 10
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"In contrast, recruitment of Vps34 into Beclin 1 positive puncta was blocked with the specific autophagy inhibitor spautin-1, which suppresses USP10 activity following decorin (XREF_FIG)."
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"Another autophagy inhibitor, spautin-1, degrades class III PI3K by inhibiting the activity of the ubiquitin specific peptidases, USP10 and USP13 (Mateo et al., 2013, Liu et al., 2011)."
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"First, spautin-1 is an inhibitor of USP10 (Liu et al., 2011), a deubiquitinating enzyme that is important for CFTR homeostasis (Bomberger et al., 2009)."
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"To directly test if spautin-1 can inhibit the deubiquitinating activity of USP10 and USP13, we tested the activity of isolated USP10 and USP13 on ubiquitinated Beclin1 in vitro."
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"USP10 inhibition by spautin-1 significantly offset the protective role of FSTL1 in T2DM mice that underwent MI (Figures 5A–H)."
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"In contrast, recruitment of Vps34 into Beclin 1 positive puncta was blocked with the specific autophagy inhibitor spautin-1, which suppresses USP10 activity following decorin (XREF_FIG)."
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"In addition, the inhibition of USP10 by spautin-1 significantly suppressed the migration and metastasis of HCC."
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"Using this assay, we found that spautin-1 inhibited USP10 and USP13 with IC 50 of ~ 0.6-0.7 microM while having no inhibitory activity toward CYLD which is also a member of ubiquitin specific peptidase family (XREF_FIG)."
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"Furthermore, our unpublished data could not recapitulate the inhibition of USP10 by spautin-1."
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"Since USP10 is known as a deubiquitinating protease of p53, inhibition of USP10 by spautin-1 may promote the degradation of p53."
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