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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

HCN1 activates cocaine. 1 / 1

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"If activation of HCN1 channels by cAMP in the orbitofrontal cortex underlies cocaine self-administration-induced deficits in the odor delayed win-shift task, this may explain the overall poorer performance found in rats with adolescence-onset experience, as chronically administered cocaine causes an upregulation of cAMP and cAMP activity is higher in the brains of adolescent than adult rats."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...