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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

SCN2A binds DHPS. 1 / 1

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"While hyperkinetic movements are not characteristic of SCN1A -linked DS, similar movement disorders are associated with SCN2A - and SCN8A -linked EIEEs; this overlap in symptomology led Sadleir et al to speculate that the early infantile SCN1A encephalopathy, like SCN2A - and SCN8A -linked EIEEs, may be associated with a gain-of-function (GOF) variant—a theory that was addressed by Berecki et al in their 2019 Annals of Neurology manuscript."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...