IndraLab

"On the other hand, genetic activation of eIF3f promoted structural muscle protein synthesis and led to muscle hypertrophy (Csibi et al., 2008)."

"For instance, eIF3f is an important housekeeping gene and is necessary for initiation of translation."

"Moreover, overexpression of eIF3f K5-10R mutant induces a significant increase in protein synthesis and hypertrophy compared to the wild type protein under normal condition (Csibi et al., 2010 )."

"Thus, we set out to determine whether eIF3f contribute in vivo to cap dependent translation."

"As shown in XREF_FIG, eIF3f wt overexpression led to increase in translation rates in muscle cells."

"Hence any reports describing pathological phenotypes stemming from altered expression of these three subunits should be at least partially regarded as a failure of the dramatically compromised eIF3 complex to ensure productive general translation initiation in sick cells; like underexpression of eIF3f in gastric, melanoma and pancreatic cancers supposedly deregulating apoptosis, eIF3f ubiquitination and proteosomal degradation during muscle atrophy, overexpression of eIF3m in human cancer cell lines and colon cancer patient tissues, as well as overexpression of eIF3c in testicular seminoma cells."

"Moreover, overexpression of eIF3f K5-10R mutant induces a significant increase in protein synthesis and hypertrophy compared to the wild type protein under normal condition (Csibi et al., 2010, Csibi et al., 2009)."

"EIF3f Activates the Cap Dependent Translation in Muscle Cells."