IndraLab

Statements



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"It has been reported that MITF downregulation is related to the suppression of the cAMP dependent melanogenic pathway stimulated by a-MSH in melanoma cells."

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"Even after l h preincubation with a-MSH, subsequent washing and reintroduction of a-MSH or ACTH produces some further stimulation of cAMP accumulation."

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"The incubation of a-MSH with tissues previously enriched with TBG induces a higher increase in the content of cAMP than that induced by a-MSH alone."

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"The second effect is a synergic action forming cAMP induced by the aMSH."

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"However, because a-MSH stimulates to a greater extent, the actual amount of cAMP in the cells is still greater in the cells treated with a-MSH."

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"A-MSH in the presence of bromocriptine produced an increase in cAMP (a similar effect was obtained when the peptide was alone)."

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"DISCUSSION We have examined the effects of a-MSH on intracellular cAMP levels in thin slices containing CP and Acc and we found that a-MSH stimulated cAMP production in a dose dependent fashion."

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"Instead, 0.1 pM HS964 was found to completely block the cAMP increase induced by a-MSH for all the four MC receptors."

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"In E15-16 rat neuronal cortical cultures ACTH (1-24), ACTH (1-17), a-MSH,, Q-MSH, ACTH (1-10), and ACTH (410) stimulate cAMP production fourfold."

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"Org2766 and a-MSH increased cyclic AMP content of Schwann cells but neither stimulated DNA synthesis when applied alone."

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"On other hand, in an accompanying article we describe the synergic action of gangliosides on the cyclic AMP release induced by a-MSH in rat brain slices (18)."

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"XREF_BIBR In the recent study by Hur, XREF_BIBR luteolin did not inhibit tyrosinase activation directly, but it concentration-dependently inhibited tyrosinase activation and melanin generation increase by a-MSH in the B16 melanoma cell as well as cAMP generation by MSH and forskolin, which identified the action mechanism of its whitening action generation."

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"A-MSH, ACTH, and P-MSH elicit a dose dependent increase in cAMP with equal potency and efficacy (47)."

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"In Hepa cells transfected with the human MC, receptor low concentrations of a-MSH and ACTH increased the intracellular cAMP content and increased the inositol phosphate production."