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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

FOXO1 phosphorylated on S256 is transcriptionally inactive. 3 / 3

3 |

➶

bel

"Insulin disrupts IRS-dependent transactivation by FKHR, and phosphorylation of Ser-256 by PKB is necessary and sufficient to mediate this effect."

10358076

➶

bel

"We found that the phosphorylation of Ser-256 and introduction of a negative charge at this site (by replacing Ser-256 with an aspartate) also inhibits transactivation by FKHR, even when the phosphorylation of Thr-24 and Ser-319 has been prevented by replacing these residues with alanine."

12228231

➶

bel

"FKHR is phosphorylated by protein kinase B (PKB) at Thr24, Ser256 and Ser319 in response to growth factors, stimulating the nuclear exit and inactivation of this transcription factor."

11980723

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...