IndraLab

Statements

EIF3F leads to the phosphorylation of RPS6KB1. 3 / 3
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reach
"We set out to determine the functional consequences of the eIF3f induced activation of mTORC1 and phosphorylation of S6K1 and 4E-BP1 (XREF_FIG), thus we investigated the formation of the translational PIC by using a cap binding assay."
20126553
sparser
"Since eIF3f serves as a connecting platform between mTOR-raptor and S6K1 in muscle cells ( xref ) and mutation of the C-terminal lysines in eIF3f increases phosphorylation of S6K1, we assessed the binding affinities of both eIF3f wt and mutant eIF3f K 5–10 R proteins with S6K1 and mTOR-raptor."
20126553
reach
"In contrast, HA tagged eIF3f mutant K 5-10 R overexpressed in mouse primary myotubes at 4 th day of differentiation was able to bind both endogenous mTOR and raptor by about 2-fold higher than HA tagged eIF3f wt leading to a higher phosphorylation and activity of S6K1 as evidenced by an increased phosphorylation of rpS6 on Ser235/236 residues (XREF_FIG)."
20126553