IndraLab

Statements

GATD3B inhibits CYLD. 5 / 5
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"It has been reported that NF-kappaB is activated via NICD and Hes1 mediated repression of the deubiquitinase CYLD and has a crucial role in the survival and drug resistance of T-ALL cells."
24301524
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"The experiments performed by Espinosa and collaborators [XREF_BIBR] in T-ALL and HEK293T cells support the notion that HES1 induced CYLD repression results in increased IKK kinase activity, IkappaBalpha degradation, RelA nuclear translocation, and NF-kappaB transcriptional activity."
24281204
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"Similarly, CYLD is downregulated by Notch and Hes1 in T-cell acute lymphoblastic lymphoma (T-ALL), thus leading to constitutive NF-kappaB activation."
22435550
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"The mechanism of Notch induced NF-kappaB activation in T-ALL involves Hes1, which transcriptionally represses CYLD (cylindromatosis), a deubiquitinase which down-regulates NF-kappaB signaling by removing the activator K63 ubiquitin chains from different elements of the NF-kappaB signalosome [XREF_BIBR]."
28561798
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"Hes1 downregulated CYLD, a negative regulator of NF-kappaB signalling, and then activated the IKK/IkappaBalpha/NF-kappaB signalling pathway."
31182110