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USP10 deubiquitinates TBP. 3 / 3
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"To test whether USP10 deubiquitinates and stabilizes TBP in mammalian cells, we overexpressed USP10 in 293T cells and monitored TBP ubiquitination levels in these cells."
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"To test whether USP10 deubiquitinates TBP through direct protein protein interactions, we used HA-TBP to co-IP with Flag-USP10 co-expressed in 293T cells."
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"Huwe1 as an E3 ligase targeting <span class="match term1">TBP</span> for K48-linked ubiquitination and proteasome-mediated degradation; We found that Huwe1 activity on <span class="match term1">TBP</span> is antagonized by the deubiquitinase <span class="match term0">USP10</span>, which protects <span class="match term1">TBP</span> from degradation."
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