IndraLab

Statements

PLK1 phosphorylates NPM1. 11 / 11
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"Plk dependent phosphorylation of NPM and B23 is cell cycle regulated."
20352051
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"During mitosis, NPM1 is found to be phosphorylated by Polo-like kinase 1 (Plk1), which might be an important event in mediating mitosis (Zhang et al. 2004)."
| PMC
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"During mitosis, NPM1 is found to be phosphorylated by Polo-like kinase 1 (Plk1), which might be an important event in mediating mitosis ."
| PMC
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"Phosphorylation of NPM by Plk1 is required for its mitotic functions ( xref ), while NPM depletion does not affect Plk1 Thr-210 phosphorylation ( xref )."
26779436
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"NPM1 phosphorylation by GRK5 and PLK1 correlates with the sensitivity of cells to undergo apoptosis with cells having higher GRK5 levels being less sensitive and cells with lower GRK5 being more sensitive to PLK1 inhibitor induced apoptosis."
22467873
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"But NPM1 is also phosphorylated at S4 by Plk1 during mitosis and by Plk-2 near the G1/S transition."
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"Phosphorylation of NPM by Plk1 is required for its mitotic functions, while NPM depletion does not affect Plk1 Thr 210 phosphorylation."
26779436
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"Plk1 can also phosphorylate NPM and B23 on S4 in mitosis XREF_BIBR."
20352051
sparser
"NPM1 phosphorylation by GRK5 and PLK1 correlates with the sensitivity of cells to undergo apoptosis with cells having higher GRK5 levels being less sensitive and cells with lower GRK5 being more sensitive to PLK1 inhibitor-induced apoptosis."
22467873
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"We also confirmed this sequential phosphorylation of NPM by CDK1-PLK1 in MCF-7 cells ( xref )."
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"Together, these results show that NPM and B23 is phosphorylated on S4 by both Plk2 and Plk1 in vitro."
20352051