IndraLab

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OTUB1 inhibits FOXM1. 4 / 9
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"A recent report showed that OTUB1 could accelerate metastasis of pancreatic cancer by inhibiting FOXM1 degradation [20]."
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"Together, these results suggest that the suppression of FOXM1 degradation by OTUB1 in response to epirubcin requires its deubiquitinating catalytic activity, further confirming that FOXM1 is a novel target of the deubiquitinase OTUB1."
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"Taking together, our present study revealed that OTUB1 played a crucial role in the development of pancreatic cancer, and NDUFS2, identified as a substrate of OTUB1, might be responsible for the observed phenotypes in the absence of OTUB1 in pancreatic cancer.A recent report showed that OTUB1 may accelerate metastasis of pancreatic cancer by inhibiting FOXM1 degradation [20]."
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"Importantly, knockdown of OTUB1 by siRNA resulted in an increase in turnover of FOXM1 in MCF-7 cells treated with the protein synthesis inhibitor cycloheximide, whereas overexpression of WT OTUB1, but not the OTUB1 (C91S) mutant, significantly enhances the half-life of FOXM1."
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