IndraLab

Statements


UCHL5 increases the amount of TGF-beta-dependent gene. 3 / 3
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"Consequently, UCH37 dramatically up-regulates TGF-beta-dependent gene expression by de-ubiquitinating and stabilizing the type I TGF-beta receptor."

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"The study hypothesized that Smad7 could act as an adaptor to recruit UCH37 to the type I TGF-beta receptor and showed that UCH37 dramatically up-regulates TGF-beta-dependent gene expression by deubiquitinating and stabilizing the type I TGF-beta receptor [XREF_BIBR]."

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"For example, Smad7 acts as an adaptor molecule to recruit Uch37 to the type I TGF-beta (transforming growth factor-beta) receptor, where Uch37 up-regulates TGF-beta-dependent gene expression by de-ubiquitinating and stabilizing the type I TGF-beta receptor."