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Statements

PSMD14 decreases the amount of SNAI1. 3 / 3
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"In addition, an in vivo ubiquitination assay was performed to validate that the ubiquitination level of SNAIL was greatly reduced by PSMD14, allowing SNAIL to escape from the degradation process ( Fig[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Two new deubiquitinating enzymatic enzymes, PSMD14 with OTUB1, can inhibit the ubiquitination level of Snail and hinder its proteasomal degradation pathway, thus enabling the accumulation of Snail in cells, and activating the Snail-mediated epithelial-stromal transformation process to promote tumor progression and metastasis in esophageal squamous carcinoma (Jing et al., 2021; Zhou et al., 2018)."
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"PSMD14 overexpression significantly lowered the expression of E-cadherin but elevated the expression of vimentin and Snail (Fig. 4B)."
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