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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Phosphorylated RPS6KB1 phosphorylates IRS1. 1 / 1

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"In our study, we found that mTORC2 deficiency could lead to increased mTORC1 activity under certain conditions [10,85] (data not shown), while over-activation of mTORC1 also restricts mTORC2 activity, either through the mTORC1-mediated phosphorylation and activation of Grb10, a negative regulator of insulin/IGF-1 receptor [12,151], or by S6K1 phosphorylation and degradation of insulin receptor substrate 1 (IRS1) to suppress mTORC2 activity [152]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...