IndraLab

Statements

Interferon activates USP18. 59 / 67
| 2 57
reach
"IFNAR2 (part of the type I IFN receptor complex (Fig. 2)) interacts directly with the IFN-induced protein Usp18, which inhibits the response to IFN-α but not to IFN-β or IFN-λ , thereby creating, at least in human cells, a negative feedback loop for IFN-α."
26194286
reach
"Resemble human USP18 and fish USP18 can be induced by IFN and IFN stimuli in vitro and in vivo."
35688049
reach
"Since USP18 is also induced by IFN, we tried to dissociate the individual contribution of USP18 and ISG15, using RNA interference."
30858391
reach
"The effects on interferon signaling of USP18 also affects tumor progression [173]."
37658402
reach
"Previous studies demonstrated that USP18 can be induced by viral infections and IFN treatment, suggesting that USP18 may play a critical role in inflammation and host innate immune response [XREF_BIBR]."
29285303
reach
"Since type 1 interferons (IFN) are known to induce IL10 and CD274, we next examined gene expression of the type 1 IFN induced response genes MX1 and USP18."
33584638
reach
"Reactome analysis revealed that commonly upregulated genes by IFN in both THP-1 and MDA-MB-231 USP18 cells were related to cytokine signaling, caspase activation, inflammasome activation, pyroptosis, and IL-1β processing (Fig. 6a)."
36646704
reach
"Firstly, like ISG15 itself, the predominant ISG15 conjugation and deconjugation enzymes UbE1L, UbcH8 and UbcM8, HERC5 and HERC6, and UBP43 and USP18 are all induced by type I IFN stimulation."
24095857
reach
"Furthermore, commonly upregulated genes by IFN in both THP-1 and MDA-MB-231 USP18 cells were related to NLRP3 and AIM2 inflammasome activation (Fig. 6a)."
36646704
reach
"In contrast, high doses of IFNα induced the negative feedback proteins USP18 and SOCS1, which synergistically act on the receptors and induce pathway desensitization."
35748700
reach
"As shown in Fig. 4 B, anti-IFN alpha/beta antibodies significantly reduced expression of the interferon stimulated genes ISG15 and USP18."
30099227
reach
"GOF STAT2 mutations are also AR, but in contrast results in hypersensitivity to type I IFN, which is mediated at least in part by preventing the USP18 protein from negatively regulating IFN receptor signaling, leading to prolonged phosphorylation of not only STAT2, but also STAT1 and JAK1 [39], with enhanced late IFN responses [61]."
38255152
reach
"Yet, the amount of ISGylated SKP2 is rather small, even in a context where global ISGylation is high as in IFN stimulated USP18 deficient fibroblasts."
30858391
eidos
"Additionally , Usp18 has been characterized in various species and demonstrated to possess interferon-sensitive response elements ( ISREs ) in its promoter region and to be strongly induced by type I IFNs [ 32,33,37 ] ."
32957626
eidos
"Usp18 is strongly upregulated by type I and type III IFNs [ 33,35,37,51,52 ] , lipopolysaccharides [ 53,54 ] , polyI :C [ 53 ] , tumor necrosis factor alpha ( TNFalpha ) [ 54 ] , or genotoxic stresses [ 35,55 ] ."
32957626
reach
"mCMV infection increased expression of representative IFN stimulated genes (IFIT3, OAS, LMP2, TGTP, and USP18) in both neonatal and adult brains to similarly large degrees."
17065212
reach
"Importantly, all three conjugation enzymes (UBA7, Ube2L6, and Herc5) as well as Usp18 are induced at the transcriptional level by Type 1 IFN signaling."
30850053
reach
"ISG15 is removed from substrates by interferon-induced ubiquitin-specific peptidase 18 or severe acute respiratory syndrome coronavirus 2-derived papain-like protease."
35952613
reach
"Another susceptibility gene in the type I interferon induced pathway is USP18."
30036494
reach
"Several reports by our group and others have supported the observation that RNase L modulates the stability of certain cellular mRNAs in the absence of viral infections, such as the RNA binding protein ELAVL1 (HuR), the double-strand RNA (dsRNA)-dependent protein kinase (PKR), the muscle differentiation transcriptional factor (MyoD), and the IFN stimulated genes 43 (ISG43) transcript."
22718976
reach
"The increased expression of dsRNA receptor TLR3 and IFN induced genes ISG56, ISG43, Mx1 and IFIT3 after stimulation with poly I : C mimicking a viral infection indicates that these cell lines can be used as effective in vitro models to study the bat 's innate immune responses to virus infection XREF_BIBR, XREF_BIBR."
25295526
reach
"The remaining injury-associated cluster was marked by upregulation of interferon-stimulated genes (Stat1, Ifit1, Rsad2, Usp18) similar to previously described IFN-response microglia (IRM) ."
37433806
reach
"Further temporal regulation of the ISG15 system by expression of the type I IFN-induced cellular deconjugase (human Usp18/mouse Ubp43), as well the role of free intracellular ISG15 in downregulating s[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
32553163
reach
"A keynote presentation by Glenn Randall (University of Chicago, USA) summarized the current understanding of the mechanisms by which interferon (IFN) controls HCV infection and described how 2 key IFN stimulated genes (ISGs), ISG15 and USP18, function within a protein modification cycle to regulate hepatic innate immunity and virus infection."
19026648
reach
"To further delineate the cause of the decreased chemokine production the expression of 2 essential ISGs in the IFN stimulated PBMC, USP18, and IRF7 was investigated."
25978633
reach
"Infection of most cell types by viruses or bacteria leads to expression of interferon stimulated genes, which include the ubiquitin-like protein ISG15 and one of its specific proteases UBP43 (USP18) (reviewed in [18])."
18817868
reach
"The expressions of IFN-stimulated genes (Irf7, Isg15, Usp18) were increased in the radioimmunotherapy group."
40087599
reach
"Cells from ATM-deficient mice that are infected with the murine γ-herpesvirus 68 (MHV68) produce higher levels of the IFN-stimulated genes (ISGs), ubiquitin specific peptidase 18 (USP18) and melanoma differentiation-associated protein 5 (MDA5) [71]."
35641341
reach
"Further mutation assays revealed that the distant ISRE motif primarily contributed to the induction of zebrafish USP18 by fish IFN and IFN stimuli."
25981749
reach
"Further temporal regulation of the ISG15 system by expression of the type I IFN-induced cellular deconjugase (human Usp18/mouse Ubp43), as well the role of free intracellular ISG15 in downregulating signaling at the type I IFN receptor in human cells, remains to be explored.We have shown that ISG15 is secreted from both lymphocytes and epithelial cells, suggesting that the ISG15 secretion mechanism is operational in a wide range of cell types."
| PMC
reach
"Such increased expression is likely due to the enhanced type I IFN signaling in Usp18 Ity9 mice since ISG15 is a well-known IFN inducible gene."
24807690
reach
"Given that type I IFN has been shown to induce IL-10 in a STAT1 dependent manner,, we examined whether the increase in type I IFN signaling in Usp18 Ity9 mice affected IL-10 production."
24807690
reach
"In the present study, we have analyzed the genes directly regulated in post-IFN-alpha receptor signaling and found that intraperitoneal administration of mouse IFN-alpha, but not human IFN-alpha, activated expression of several prototypic IFN stimulated genes (ISGs), in particular signal transducers and activators of transcription (STAT1), IFN induced 15 kDa protein (ISG15), ubiquitin specific proteinase 18 (USP18) and guanylate binding protein 3 (GBP3) in the brain."
17486106
reach
"We find that interfering with IFN-I signaling pathway in infected patients, notably by targeting the interferon stimulated gene USP18, resulted in reduced PTEN expression similar to those observed in uninfected control donors."
31658294
reach
"On the other hand, higher levels of type I interferon may increase the expression of these negative regulators: recruitment of USP18 to the type I interferon receptor IFNAR desensitizes cells to any additional IFN-activating stimuli (96, 97), while increased SOCS1 expression suppresses responses to pathogens that activate interferon-pathway signaling like LPS (98)."
35471841
reach
"44 In parallel, Ad26.ZEBOV induced the upregulation of genes induced by IFNs, such as TFs ( IRF9 , IFI6 , IFIT5 , and IFIT1 ); nucleic acid sensors ( DDX58 and DHX58 ); oligoadenylate synthases ( OAS3[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
37691146
reach
"These patients were deficient in ISG15, leading to increased S-phase kinase-associated protein 2 (SKP2) mediated proteolysis of USP18 and subsequently an upregulated IFN gene signature [80] ."
25814341
reach
"For example, hepatic mRNA expression of IFN stimulated genes (ISGs, such as ISG15, OAS, IFI, IP10, and viperin) and IFN related pathway genes (MX and USP18) correlate with responses to peg-IFNalpha and RBV combination therapy for CH-C XREF_BIBR - XREF_BIBR."
24819603
reach
"USP18 is transcriptionally upregulated by IFN treatment and exerts inhibition of IFN-alpha signaling at the receptor level, forming a negative feedback loop."
32945770
reach
"The inductions of un phosphorylated IFN stimulated gene factor 3 (U-ISGF3) -associated ISGs, IFN stimulated gene 15 (ISG15) and ubiquitin specific protease 18 (USP18), were also evaluated."
29464023
reach
"Transfected BoMacs displayed altered cell morphology [19, 24] and modulated expression of the IFN-stimulated genes (ISG), UBP43 (alias USP18) and ISG15 [19]."
37276213
reach
"These IFN system genes include the dsRNA signal sensing factor TLR3, IFN, IFN signal transduction factor STAT1, IFN regulatory factor IRF7, putative IFN antiviral effectors Mx1, Mx2, PKR like, Viperin, IFI56, and other IFN stimulated genes (ISGs) IFI58, ISG15-1, ISG15-2, USP18, Gig1 and Gig2."
16887185
reach
"USP18 protein accumulated with similar kinetics in cells treated with IFN beta or IFN lambda1, reaching maximum level between 8 and 16 hr of stimulation (XREF_FIG)."
21779393
reach
"Treatment with 2-DG or DCA reduced the level of the DEGs related to antiviral mechanism by IFN-stimulated genes (mainly Isg15, Usp18 and Mx2) in the brain of infected animals, being again more marked for DCA (Fig. 4D)."
37759218
reach
"The kinetics of USP18 upregulation by IFN is heterogeneous in single cells."
32945770
reach
"In contrast, in those cells that progressed beyond this phase, the IFN treatment could not initiate USP18 induction until the next cell cycle, resulting in extended delay times proportional to the times needed to reach the next cell cycle (XREF_FIG)."
32945770
reach
"If cells are exposed to IFN when they pass the G1/S phases, the IFN treatment can not initiate USP18 induction until the G1 phase of the next cell cycle, causing a dramatic delay in the induction kinetics."
32945770
reach
"USP18 is promptly induced by viral infection and IFN signaling [XREF_BIBR]."
32276399
reach
"In addition, USP18, which is increased by interferon signaling and is stabilized through a noncovalent association with ISG15, also acts to inhibit STAT1 activation by type I interferons to limit undue interferon signaling (17, 18)."
39159817
reach
"A well-studied negative regulator of IFNAR signaling is the ubiquitin-specific protease 18 (USP18), which is induced by IFN signaling and is recruited to the IFNAR2 receptor subunit to terminate signaling (Arimoto et al, 2017; Malakhova et al, 2006); interestingly, USP18 expression is decreased by BMP6 (Eddowes et al, 2019)."
38308064
reach
"In terms of molecular pathways activated, interferon-a exposure caused an increase in the expression of interferon-stimulated gene 15 (ISG15), ubiquitin-specific peptidase 18 (USP18), and interleukin-6 (IL-6), set off by signal transducer and activator of transcription 1 (STAT-1)."
38954533
reach
"Additionally, the activated IFN-I signaling cascade induces interferon-stimulated gene 15 (ISG15) and ubiquitin-specific protease 18 (USP18) (Figure 1)."
38675828
reach
"An enhanced interferon-mediated resistance of USP18-deficient mice against lymphocytic choriomeningitis (LCMV) and vesicular stomatitis virus (VSV) infection was observed suggesting a role of USP18 in[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
17961905
reach
"Finally, we assessed IFN induced USP18 accumulation in cells silenced for SKP2."
25307056
reach
"Moreover, interferon-alpha increased the expression of interferon stimulated gene 15 (ISG15), ubiquitin specific peptidase 18 (USP18), and interleukin-6 (IL-6) via activation of STAT1."
29040650
reach
"A ubiquitin deconjugating enzyme, ISG43, is also induced by IFN (Li et al., 2000b) ."
14550502
reach
"USP18 is induced by type I IFN, which requires JAK/STAT signaling pathway [ 27 ]."
35390466
reach
"The in vitro IFN induced USP18 mRNA change (USP18 IFN -N) was measured via comparison of quantitative PCR determined USP18 transcription levels of BPMCs cultured with and without IFN stimulation."
31074081
reach
"The IFN induced Janus kinase (Jak)-signal transducer and activator of transcription protein (STAT) pathway was less frequently activated in patients with cleaved MAVS, and there was a significant inverse correlation between cleavage of MAVS and the expression level of the IFN stimulated genes IFI44L, Viperin, IFI27, USP18, and STAT1."
20044805