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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

S-(+)-ketamine inhibits HCN1. 2 / 2

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"HCN1 channels are more potently inhibited by S-(+)-ketamine than racemic ketamine, consistent with its anesthetic actions in vivo [XREF_BIBR]."

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"Whereas such in vitro results provide a strong correlative argument to implicate NMDA receptors, we find that the same case can be made for HCN1 channels : EC 50 values obtained for ketamine inhibition of HCN1 channels are within a clinically relevant range and HCN1 channels are more potently inhibited by S-(+)-ketamine than racemic ketamine."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...