IndraLab

Statements

TP53 is methylated on lysine. 12 / 12
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"Mono- or di-methylation of TP53 at four C-terminal lysine residues by at least six different lysine methyltransferases facilitates binding by TIP60, PHF20, L3MBTL1 and 53BP1 to TP53 ( xref , xref , xref ) ( xref ; xref )."
24395704
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"To further the analogy to histone modification, the same p53 lysine residues that are methylated are also subject to other modifications like acetylation, sumoylation and ubiquitylation [ xref ]."
18923809
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"P53 is methylated at C-terminal lysine residues: K370, K372 and K382."
24797517
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"For example, methyltransferase Set 9 can specifically methylate lysine residues in p53 to regulate its target gene expression [ xref ]."
29986538
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"To this point, three different methyltransferases have been shown to be able to methylate C-terminal lysine residues of p53."
19450511
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"These results disfavour a role for JMJD3 in the regulation of p53 C-terminal methylation, however, we cannot rule out that JMJD3 is involved in regulating p53 methylation at other lysine residues than the tested ones, or that additional co-factors are required for an efficient enzymatic removal of methylation."
24797517
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"The p53 protein is methylated at lysine residues in its C-terminal regulatory region p53, which stabilizes it, restricts it to the nucleus, and enhances its ability to transcriptionally transactivate target genes (reviewed in xref )."
33193732
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"Interestingly, some lysine residues of p53 that are modified by acetylation can also be methylated [ xref ]."
28208785
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"Genotoxic stress can induce methylation of p53 in at least three different lysine residues, which mediate activation or repression of p53-dependent apoptosis ( Chuikov et al., 2004; Huang et al., 2006[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
20603083
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"Some HMTs (SETD8 and SMYD2) have been found to regulate the methylation of non-histone proteins in particular p53 in lysine residues."
30834247
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"For instance, histone lysine methyltransferases KMT5 (Set9), KMT3C (Smyd2), and KMT5A (Set8) were reported to methylate p53 at specific C-terminal lysine residues."
34888311
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"Thus, methylation and acetylation at different lysine residues of p53 and their interplay govern cellular response to spontaneous/endogenous and exogenous damage, respectively."
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