IndraLab

Statements

Pan3L binds PAN2. 3 / 3
| 3
sparser
"We propose that the first phase of deadenylation, involving differential actions of Pan2–Pan3S and Pan2–Pan3L, represents a previously unsuspected step of mRNA “maturation” in the cytoplasm, with the potential to modulate critical mRNP remodeling and influence the cytoplasmic fate of mRNA."
28559491
sparser
"Given that Pan 2 and Pan3L are both shuttling proteins ( xref ) but Pan3S is not (), we propose that Pan3L may associate with Pan2 in the nucleus and inhibit Pan2 deadenylase activity."
28559491
sparser
"As several recent structural and in vitro studies ( xref ; xref ; xref ; xref ) showed that Pan3 is dimeric when complexed with Pan2, Pan3S may associate with Pan2–Pan3L complex via dimerization with Pan3L in the cytoplasm."
28559491